Key result
Imputing early and midlife cardiovascular risk factors shows acceptable accuracy in pooled cohorts.
Why the study?
Understanding how early and midlife cardiovascular disease risk factor exposures affect later life outcomes is useful for prevention strategies, but few US cohorts have followed participants from early adulthood to late life.
Can early and midlife cardiovascular disease risk factors be accurately imputed using a pooled cohort approach to assess their effects on later life outcomes?
Cohort (n=15,001)
Yes
Can early and midlife cardiovascular disease risk factors be accurately imputed using a pooled cohort approach to assess their effects on later life outcomes?
Imputed cardiovascular disease risk factors using a pooled cohort approach show acceptable accuracy and may be useful for assessing the effects of early and midlife exposures on later life outcomes.
No takes yet. Share an insight, caveat, or question.
May aid life-course CV epidemiology in existing cohorts; leaves open validation for outcome prediction or diverse populations.
Hazzouri et al. (2018) conducted a cohort in Cardiovascular disease risk factors (n=15,001). Imputation of early and midlife CVDRF trajectories was evaluated on Imputation accuracy (correlations and agreement of true and imputed CVDRF summary measures). Imputing early and midlife cardiovascular disease risk factors using pooled cohorts demonstrated acceptable accuracy, with correlations of true and imputed measures ranging from 0.53 to 0.99.
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