Key result
Vascular pericytes and the broader vasculature play a critical, underappreciated role in insulin secretion, islet function, and peripheral insulin delivery in the pathogenesis of type 2 diabetes.
Design
Review
Authors
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Shifts T2D research focus to vascular mechanisms; leaves open whether pericyte targeting alters clinical outcomes.
This review highlights the underappreciated role of vascular pericytes in insulin secretion and peripheral insulin delivery, offering potential new mechanistic insights into type 2 diabetes pathogenesis.
Richards et al. (2010) conducted a review in Type 2 diabetes and insulin resistance. Vascular pericytes and endothelial cells was evaluated. Vascular pericytes and the broader vasculature play a critical, underappreciated role in insulin secretion, islet function, and peripheral insulin delivery in the pathogenesis of type 2 diabetes.