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AIM: Hydrogels are three-dimensional, water-rich polymer networks that enhance drug delivery, hydration, and tolerability in topical acne therapy. This systematic review and meta-analysis evaluated the efficacy and safety of hydrogel-based formulations for acne treatment. METHODS: ), and publication bias (funnel plot, Egger's test) were assessed. (PROSPERO: CRD420251140597). RESULTS: = 86%), all showed consistent direction of effect favoring hydrogels. No serious events reported. CONCLUSION: Topical hydrogels effectively reduce acne lesions with excellent safety and tolerability. Larger, well-designed RCTs are warranted to confirm long-term outcomes.
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Abunasser et al. (2026) studied this question.
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