Key result
HF alters stroke work mechanics, with radial pumping contributing ~56% of the total.
Why the study?
How do longitudinal and radial pumping contribute to stroke work in controls and heart failure patients using a novel force-length loop method?
Observational
How do longitudinal and radial pumping contribute to stroke work in controls and heart failure patients using a novel force-length loop method?
A novel noninvasive method using CMR and cuff pressure reveals that longitudinal pumping is more energy efficient and its contribution to stroke work is reduced relative to radial pumping in heart failure patients.
Suggests longitudinal efficiency as HF target; extends noninvasive mechanics assessment but remains hypothesis-generating.
A novel method for quantifying the contributions of longitudinal and radial pumping to stroke work using global left ventricular force-length loops was proposed and validated, which can be quantified noninvasively using cardiovascular magnetic resonance and brachial cuff pressure. We found that longitudinal and radial pumping contributes equally to stroke work in controls and 44/56% in heart failure patients, and that the longitudinal pumping is more energy efficient in delivering stroke volume than radial pumping.
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Seemann et al. (2020) conducted an observational in Heart failure. Noninvasive quantification using cardiovascular magnetic resonance and brachial cuff pressure vs. Controls was evaluated on Contribution of longitudinal and radial pumping to stroke work. Noninvasive quantification showed longitudinal and radial pumping contribute equally to stroke work in controls, but 44% and 56% respectively in heart failure patients.
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