Key result
Pericardiotomy during acute pulmonary artery constriction increased left ventricular stroke volume by 35% in anesthetized dogs.
Why the study?
Does pericardiotomy improve left ventricular function during acute pulmonary hypertension in anesthetized dogs?
Population
6 anesthetized dogs
Comparison
Pericardiotomy during pulmonary artery… vs Pulmonary artery constriction with closed…
Design
Preclinical
Authors
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Indicates pericardial constraint limits LV filling in acute experimental PH; leaves open clinical translation.
Does pericardiotomy improve left ventricular function during acute pulmonary hypertension in anesthetized dogs?
Pericardiotomy improves left ventricular stroke volume during acute pulmonary hypertension by relieving external constraint to LV filling.
Belenkie et al. (2004) studied Acute pulmonary hypertension (n=6). Pericardiotomy vs. Pulmonary artery constriction with closed pericardium was evaluated on Left ventricular stroke volume. Pericardiotomy during acute pulmonary artery constriction increased left ventricular stroke volume by 35% in anesthetized dogs.
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