Key result
Female sex is associated with ~21% more ACE inhibitor adverse events, potentially from higher doses.
Why the study?
Are there sex differences in spontaneously reported adverse drug events for common antihypertensive drugs?
Cross-Sectional
Are there sex differences in spontaneously reported adverse drug events for common antihypertensive drugs?
Effect estimate: OR 1.21 (95% CI 1.09-1.35)
Women have a higher prevalence of spontaneously reported adverse drug events for most common antihypertensive drugs compared to men, which may be linked to differences in dose exposure.
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May warrant sex-specific ADE monitoring in hypertension; hypothesis-generating for dose-optimization trials.
Rydberg et al. (2018) conducted a cross-sectional in Hypertension (users of common antihypertensive drugs). Female sex vs. Male sex was evaluated on Prevalence of spontaneously reported adverse drug events (ADEs) for ACE inhibitors adjusted for individuals exposed (OR 1.21, 95% CI 1.09-1.35). Women had a higher prevalence of reported adverse drug events in six out of ten antihypertensive drug groups, including ACE inhibitors (OR 1.21), potentially linked to higher dose exposure.
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