Key result
Higher Life's Essential 8 score linked to ~23% lower risk of incident diabetic kidney disease.
Why the study?
Diabetic kidney disease is a common complication complicating diabetes management, but no prospective study had examined its association with Life's Essential 8.
Does a higher Life's Essential 8 score reduce the risk of diabetic kidney disease in patients with diabetes?
Cohort (n=7,605)
Does a higher Life's Essential 8 score reduce the risk of diabetic kidney disease in patients with diabetes?
Effect estimate: HR 0.77 (95% CI 0.69-0.87)
p-value: p=<0.05
Higher Life's Essential 8 scores are associated with a significantly lower risk of developing diabetic kidney disease in patients with diabetes.
Background Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk. Methods and Results A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing ( P ‐trend<0.05), and the linearity assumption for this relationship ( P ‐nonlinear=0.685) had been satisfied. Adjusted hazard ratios (HRs) for the highest tertile were 0.77 (95% CI, 0.69–0.87) and 0.70 (95% CI, 0.62–0.78) in baseline and time‐updated LE8 scores, respectively, compared with the lowest tertile. Adjusted HR was 0.53 (95% CI, 0.41–0.69) for the stable‐high pattern compared with the stable‐low pattern. Conclusions Although LE8 is an indicator of cardiovascular health, the beneficial impact of a high LE8 score is also evident in the protection of renal health among patients with diabetes.
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Gao et al. (2023) conducted a cohort in Diabetic kidney disease (n=7,605). Life's Essential 8 (LE8) score vs. Lowest tertile of LE8 score was evaluated on Diabetic kidney disease incidence (HR 0.77, 95% CI 0.69-0.87, p=<0.05). A higher Life's Essential 8 score was associated with a significantly lower risk of incident diabetic kidney disease compared with the lowest tertile (HR 0.77; 95% CI 0.69-0.87).
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