Key result
Moderate asthma is linked to subclinical RV dysfunction including lower RV isovolumic acceleration.
Why the study?
Studies investigating asthma and its implications on new right ventricular parameters are very rare, prompting evaluation of right ventricular functions in moderate asthma before the development of pulmonary hypertension.
Does moderate asthma cause early impairment of right ventricular functions measured by RV isovolumic acceleration compared to healthy individuals?
Case-Control (n=81)
Does moderate asthma cause early impairment of right ventricular functions measured by RV isovolumic acceleration compared to healthy individuals?
p-value: p=<0.001
Moderate asthma is associated with subclinical right ventricular dysfunction, which can be sensitively detected using the RV isovolumic acceleration index.
May warrant RV monitoring in moderate asthma; hypothesis-generating and requires prospective validation before practice change.
Introduction: Asthma is a common chronic lung disease that affects people all over the world. Pulmonary hypertension and right ventricular (RV) dysfunction are possible complications that may develop in the advanced stages of asthma. However, the number of studies investigating asthma and its implications on new RV parameters are very rare. This study aims to evaluate the RV functions in patients with moderate asthma before the development of pulmonary hypertension. Patients and Methods: Forty-one patients with moderate asthma and 40 healthy individuals were enrolled in this case-control study. All participants underwent a detailed two-dimensional echocardiographic examination. RV functions were measured through RV isovolumic acceleration (IVA) index in addition to conventional parameters. RV IVA, a tissue doppler derived parameter, was calculated as the ratio between maximum isovolumic myocardial velocity during isovolumic contraction and the time interval from the onset of this wave to the time at its maximum velocity. Results: There were no significant differences between the two groups in terms of baseline clinical characteristics, laboratory findings and echocardiographic parameters measuring left ventricular functions (p> 0.05). In asthmatic patients, RV isovolumic relaxation time and RV myocardial performance index were higher (p= 0.027 and p<0.001 respectively), while RV fractional area change, tricuspid annular plane systolic excursion (TAPSE) and RV IVA values were all lower (p<0.001). RV IVA was found to be inversely proportional to asthma duration. TAPSE [β= 0.632, 95% CI= (0.121) - (0.225), p<0.001] and pulmonary artery systolic pressure [β= -0.188, 95% CI= (-0.057) - (-0.003), p= 0.032] were shown as independent predictors of RV IVA. Conclusion: Asthma is an important disease that may result in subclinical RV dysfunction even before the development of pulmonary hypertension. RV IVA, an easily obtained and load-independent parameter, may be a useful and reliable index that sensitively analyzes subtle deteriorations in the contractile function of RV in asthmatic patients. RV IVA may also correlate with asthma duration.
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Karasu et al. (2022) conducted a case-control in Moderate asthma (n=81). Moderate asthma vs. Healthy individuals was evaluated on Right ventricular functions including RV isovolumic acceleration (IVA) index (p=<0.001). Moderate asthma was associated with subclinical right ventricular dysfunction, including significantly lower RV isovolumic acceleration (p<0.001) compared to healthy controls.
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