Key result
Surgical ventricular reconstruction and cardiac resynchronization therapy with a defibrillator improved NYHA class from III to I and LVEF from 17.5% to 31.7% in a patient with dilated phase of hypertrophic cardiomyopathy.
Why the study?
Does left ventricular reconstruction surgery combined with CRT-D improve symptoms and prevent re-hospitalization in a patient with drug-resistant severe heart failure due to the dilated phase of hypertrophic cardiomyopathy?
Case Report (n=1)
No
Does left ventricular reconstruction surgery combined with CRT-D improve symptoms and prevent re-hospitalization in a patient with drug-resistant severe heart failure due to the dilated phase of hypertrophic cardiomyopathy?
Left ventricular reconstruction surgery combined with CRT-D may be an effective therapeutic option for drug-resistant severe heart failure in patients with the dilated phase of hypertrophic cardiomyopathy.
May warrant individualized consideration in refractory dilated-phase HCM; hypothesis-generating and requires prospective confirmation before broader adoption.
We herein report the case of a 61-year-old woman with dilated phase of hypertrophic cardiomyopathy (D-HCM) who had been diagnosed with HCM 17 years previously. On admission, her left ventricle (LV) had marked dilation, dyssynchrony with diffuse severe hypokinesis, and ventricular tachycardia. She had two mutations in the cardiac myosin binding protein-C gene, which were suspected to be the causes of the D-HCM. We performed LV reconstruction surgery and cardiac resynchronization therapy with a defibrillator for her drug-resistant severe heart failure. After surgery, her New York Heart Association class dramatically improved, and she has not been re-hospitalized since these treatments.
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Sato et al. (2012) conducted a case report in Dilated phase of hypertrophic cardiomyopathy (n=1). Surgical ventricular reconstruction and cardiac resynchronization therapy with a defibrillator was evaluated on NYHA class and left ventricular function. Surgical ventricular reconstruction and cardiac resynchronization therapy with a defibrillator improved NYHA class from III to I and LVEF from 17.5% to 31.7% in a patient with dilated phase of hypertrophic cardiomyopathy.
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