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July 15, 2014Current Opinion in HematologyOpen Access

Shaping the platelet response to vascular injury

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Key result

Coordinated platelet activation pathways clarify thrombosis biology and potential antiplatelet agent risks.

Design

Review

Authors

TSTimothy J. StalkerThomas Jefferson UniversityJWJohn D. WelshUniversity of PennsylvaniaLBLawrence F. BrassCross-Cutting Cardiology

Discussion

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Overview

Should not yet change antiplatelet practice; hypothesis-generating for spatially targeted therapies.

Key Points

  • To synthesize emerging models of how diverse signaling pathways integrate dynamically within growing thrombi during in vivo hemostasis.
  • Reviewed recent in vivo genetic and pharmacological studies investigating platelet activation pathways during vascular injury.
  • Evaluated physiological mechanisms governing agonist distribution and solute transport dynamics across thrombus architectures.
  • Platelet activation during hemostasis and thrombosis is heterogeneous rather than uniform throughout a hemostatic plug.
  • Activation pathways function in a coordinated, spatiotemporally regulated network governed by changing local agonist concentrations and solute transport.
  • Understanding spatial platelet signaling provides critical mechanistic context for predicting the efficacy and bleeding risks of antiplatelet therapies.

PICO

P
Population
Hemostasis and thrombosis

Understanding the spatial and temporal coordination of platelet signaling networks provides insights into hemostasis, thrombosis, and the mechanisms of antiplatelet agents.

Cite This Study

Stalker et al. (2014) conducted a review in Hemostasis and thrombosis. Platelet activation pathways are coordinated in time and space during hemostasis and thrombosis, providing insights into platelet biology and the potential risks of antiplatelet agents.

synapsesocial.com/papers/6a0ba9fa4f6759c6fca256bdhttps://doi.org/10.1097/moh.0000000000000070
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