Why the study?
Patients admitted with ADHF have a poor prognosis and quality of life due to dyspnea and edema, warranting evaluation of a short course of tolvaptan to treat volume overload.
Does a short course of tolvaptan (15 mg/day for 4 days) reduce body weight and volume overload in hospitalized ADHF patients refractory to conventional diuretics?
Population
91 hospitalized ADHF patients with volume overload despite conventional diuretics
Comparison
Tolvaptan 15 mg/day for 4 days vs matching placebo
Design
Phase III multicenter randomized double-blind placebo-controlled study
Follow-up
4 days (1 month for all-cause mortality)
Authors
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Supports short-course tolvaptan in diuretic-refractory ADHF; extends RCT evidence for aquaretics in acute volume overload.
Does a short course of tolvaptan (15 mg/day for 4 days) reduce body weight and volume overload in hospitalized ADHF patients refractory to conventional diuretics?
A short 4-day course of tolvaptan effectively reduces body weight and improves fluid balance in hospitalized ADHF patients with volume overload despite conventional diuretic therapy.
Lin et al. (2022) studied this question.