Prediction of individual genetic risk to disease from genome-wide association studies
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Implication
Randomized trial investigates genetic risk prediction in individuals, suggesting improved disease identification strategies.
Key Points
- This research aims to assess how multiple genetic risk alleles contribute to predicting disease risk in individuals.
- Investigated effect sizes and number of risk loci for complex diseases based on prevalence and heritability.
- Proposed a method for genetic risk assessment using dense genome-wide SNP panels.
- Used simulation to evaluate the prediction approach and the requirement for a case-control study to identify risk loci.
- For diseases influenced by over 50 loci, a case-control study can select about 75 loci explaining >50% of genetic variance.
- Individuals in the top 5% predicted risk group are 3-7 times more likely to develop the disease compared to the average population.
- Prediction accuracy is influenced by disease heritability and prevalence rates.
Cite This Study
Wray et al. (2007) studied this question.