Key result
Coexpression of human KvLQT1 with human or rat minK subunits increased single-channel conductance from 0.7 pS to 4.5 pS and 6.5 pS, respectively, accounting for the increased macroscopic current.
Why the study?
Does coexpression of minK subunits with KvLQT1 alter the single-channel conductance and current properties in Xenopus oocytes?
Population
Xenopus oocytes expressing human KvLQT1 channel subunits alone or in conjunction with human or rat minK…
Comparison
Coexpression of KvLQT1 with human or rat minK… vs Expression of human KvLQT1 subunits alone
Design
Preclinical
Authors
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Findings in oocytes extend minK-KvLQT1 conductance data; leaves open native cardiomyocyte and clinical relevance.
Does coexpression of minK subunits with KvLQT1 alter the single-channel conductance and current properties in Xenopus oocytes?
Absolute Event Rate: 4.5% vs 0.7%
The minK subunit increases the macroscopic potassium current of KvLQT1 channels by increasing their apparent single-channel conductance.
Yang et al. (1998) studied IKs Potassium Channels. Coexpression with minK gene product vs. KvLQT1 subunits alone was evaluated on Single-channel conductance. Coexpression of human KvLQT1 with human or rat minK subunits increased single-channel conductance from 0.7 pS to 4.5 pS and 6.5 pS, respectively, accounting for the increased macroscopic current.
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