Key result
Senile amyloidosis plays an increasingly recognized role in mechanisms underlying HFpEF and AF.
Why the study?
The mechanisms underlying HFpEF and AF, including their intricate interaction and the role of the two types of senile amyloidosis, have not been fully resolved.
Senile amyloidosis, specifically ATTRwt and IAA, plays a significant role in the pathogenesis of HFpEF and AF, highlighting the need for improved diagnostic and therapeutic strategies.
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Suggests ATTRwt and atrial amyloid contribute to HFpEF-AF coexistence; leaves open whether amyloid-targeted therapies improve outcomes.
Berg et al. (2019) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF). Senile amyloidosis, including wild-type transthyretin-derived and isolated atrial amyloidosis, plays an increasingly recognized role in the underlying mechanisms of HFpEF and atrial fibrillation.