What question did this study set out to answer?

To review sex-specific differences across the colorectal cancer pathway—from screening and presentation to cancer stage and survival—to identify where interventions can reduce mortality gaps.

September 20, 2018BMC CancerOpen Access

A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK

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To review sex-specific differences across the colorectal cancer pathway—from screening and presentation to cancer stage and survival—to identify where interventions can reduce mortality gaps.
Conducted a cross-sectional review using United Kingdom national cancer registry datasets.
Evaluated sex disparities across disease incidence, bowel screening uptake, routes to diagnosis, staging at presentation, and age-standardised 5-year survival.
Colorectal cancer incidence was higher in males with an earlier age distribution, alongside distinct anatomical site variations between sexes.
Screening uptake was higher in females under 69 years of age; however, females presented more often via emergency routes, whereas males were more frequently diagnosed through screening and two-week-wait pathways.
Advanced cancer stage at diagnosis and age-standardised 5-year survival showed minimal differences between sexes, indicating that higher male mortality is primarily driven by pre-diagnosis incidence factors.

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Implication

Cross-sectional review reveals higher colorectal cancer incidence in males despite similar survival rates across sexes, suggesting pre-diagnosis drivers of disparity.

Cite This Study

White et al. (2018) studied this question.

synapsesocial.com/papers/6a0bf5b6e8a76b3043884c14 https://doi.org/10.1186/s12885-018-4786-7

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Implication

Cross-sectional review reveals higher colorectal cancer incidence in males despite similar survival rates across sexes, suggesting pre-diagnosis drivers of disparity.

A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK

Key Points

Discussion

Implication

Cite This Study

A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK

Key Points

Discussion

Implication

Cite This Study

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