Multidimensional Proteomics Reveals the Pro-apoptotic Mechanism of Platycodin D: Targeting RFC4 to Regulate the Notch Signaling Axis in Non-Small Cell Lung Cancer

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This study aims to uncover the pharmacological mechanisms of Platycodin D in non-small cell lung cancer.
Utilized thermal proteome profiling (TPP) and molecular docking to identify PD targets.
Conducted Western Blot and immunoprecipitation-Western Blot (IP-WB) for pathway analysis.
Performed proteomic and ubiquitinomic profiling post PD treatment for functional exploration.
RFC4 identified as a binding target of PD through TPP, promoting Notch1 and Notch3 degradation.
Differentially expressed proteins involved in ferroptosis and ubiquitination were detected after PD treatment.
Ubiquitin proteome analysis indicated changes in proteins associated with the Notch pathway.

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Investigates Platycodin D's regulatory impact on Notch signaling in non-small cell lung cancer, indicating its therapeutic potential.

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Zhang et al. (2026) studied this question.

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