Pan-immune-inflammation value and platelet indices as mortality markers in intensive care patients with sepsis

Objective: Sepsis remains a major global health problem with high morbidity and mortality rates, mostly in intensive care unit (ICU) settings. The Pan-Immune Inflammation Value (PIIV), a composite marker derived from neutrophil, monocyte, platelet, and lymphocyte counts, has recently emerged as a potential indicator of systemic inflammation. This study aimed to evaluate the prognostic performance of PIIV and platelet-derived indices, including mean platelet volume (MPV) in predicting 30-day mortality among ICU-admitted sepsis patients.Methods: This retrospective study included 191 adult patients with sepsis admitted to the ICU of a tertiary care hospi-tal. Laboratory parameters, including PIIV, MPV, PLR, and lactate, along with various clinical and laboratory parame-ters were recorded within the first 24 hours of ICU admission. Logistic regression analysis (LRA) and receiver operat-ing characteristic curve (ROC) analysis were performed to determine predictors of 30-day mortality.Results: Of the total cohort, 96 patients (50.3%) died within 30 days after ICU admission. PIIV, MPV, and lactate levels were found to be elevated in non-survivors (p=0.001, p=0.003, and p=0.001, respectively). In multivariate LRA, PIIV (OR: 1.235; 95% CI: 1.086–1.404; p=0.001), MPV (OR: 1.346; 95% CI: 1.111–1.630; p=0.002), lactate, and urea were independently associated with mortality. ROC analysis showed that PIIV had an AUROC of 0.643 at a cut-off value of ≥1.2, while MPV had an AUROC of 0.623 at a cut-off of ≥11.5 fL.Conclusion: Integrating PIIV and MPV into the clinical assessment of sepsis patients may improve decision-making in the management of critically ill septic patients in intensive care units.