What question did this study set out to answer?

To develop and evaluate a thermo-sensitive silver nanoparticle hydrogel composite designed to act as an antibacterial nutrient scaffold capable of filling irregular wound cavities and accelerating tissue repair.

June 5, 2023Open Access

Antibacterial Thermo-Sensitive Silver Hydrogel Nanocomposite Improves Wound Healing

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Authors

NANafise AmiriUniversity of British Columbia SGSahand GhaffariUniversity of British Columbia IHIda HassanpourUniversity of British Columbia

Discussion

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Overview

Preclinical study demonstrates accelerated wound closure and potent antibacterial activity in rat models, suggesting a safe functional scaffold for chronic ulcers.

Key Points

To develop and evaluate a thermo-sensitive silver nanoparticle hydrogel composite designed to act as an antibacterial nutrient scaffold capable of filling irregular wound cavities and accelerating tissue repair.
Synthesized spherical silver nanoparticles (AgNPs) and reconstituted them into collagen-based hydrogels at concentrations of 200, 400, and 600 ppm.
Assessed antibacterial efficacy in vitro and in vivo using a rat subcutaneous implant infection model.
Evaluated wound closure, re-epithelialization, cytocompatibility, and systemic toxicity using a splinted excisional wound model in rats.
Bacterial inhibition in vitro was dose-dependent across all silver hydrogels (p < 0.05), reaching a peak reduction of 4.56 ± 0.26 LOG CFU/mL in the 600 ppm cohort (P < 0.001).
All silver nanocomposite concentrations showed significant in vivo antibacterial clearance in subcutaneous implant models (P < 0.0001).
Application of the hydrogel composite accelerated wound closure and re-epithelialization without inducing cytotoxicity or significant shifts in systemic hematological and biochemical markers.

Cite This Study

Amiri et al. (2023) studied this question.

synapsesocial.com/papers/6a0c11bb63ad68335d2322d2 https://doi.org/10.20944/preprints202306.0308.v1

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June 5, 2023Open Access

Antibacterial Thermo-Sensitive Silver Hydrogel Nanocomposite Improves Wound Healing

View Full Paper

Ask AI

Bookmark

Authors

NANafise AmiriUniversity of British Columbia SGSahand GhaffariUniversity of British Columbia IHIda HassanpourUniversity of British Columbia

Discussion

Member takes

Overview

Preclinical study demonstrates accelerated wound closure and potent antibacterial activity in rat models, suggesting a safe functional scaffold for chronic ulcers.

Key Points

To develop and evaluate a thermo-sensitive silver nanoparticle hydrogel composite designed to act as an antibacterial nutrient scaffold capable of filling irregular wound cavities and accelerating tissue repair.
Synthesized spherical silver nanoparticles (AgNPs) and reconstituted them into collagen-based hydrogels at concentrations of 200, 400, and 600 ppm.
Assessed antibacterial efficacy in vitro and in vivo using a rat subcutaneous implant infection model.
Evaluated wound closure, re-epithelialization, cytocompatibility, and systemic toxicity using a splinted excisional wound model in rats.
Bacterial inhibition in vitro was dose-dependent across all silver hydrogels (p < 0.05), reaching a peak reduction of 4.56 ± 0.26 LOG CFU/mL in the 600 ppm cohort (P < 0.001).
All silver nanocomposite concentrations showed significant in vivo antibacterial clearance in subcutaneous implant models (P < 0.0001).
Application of the hydrogel composite accelerated wound closure and re-epithelialization without inducing cytotoxicity or significant shifts in systemic hematological and biochemical markers.

Cite This Study

Amiri et al. (2023) studied this question.

synapsesocial.com/papers/6a0c11bb63ad68335d2322d2 https://doi.org/10.20944/preprints202306.0308.v1

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