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November 6, 2001Proceedings of the National Academy of Sciences

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

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Authors

TOTaku OkazakiThe University of TokyoAMAkito MaedaNihon UniversityHNHiroyuki NishimuraFukuoka Industrial Technology Center

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Okazaki et al. (2001) studied this question.

synapsesocial.com/papers/6a0c4335e8a76b3043886b22https://doi.org/10.1073/pnas.231486598
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Novel Phosphotyrosine Motif with a Critical Amino Acid at Position −2 for the SH2 Domain-mediated Activation of the Tyrosine Phosphatase SHP-11997 · 198 citations
  2. 2Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses1998 · 502 citations