Aerobic exercise serves as an effective adjunctive therapy for pulmonary hypertension by improving exercise capacity, reducing mean pulmonary arterial pressure, and modifying vascular remodeling.
Does aerobic exercise modify vascular remodeling in patients with pulmonary hypertension?
This review highlights the pathogenesis of pulmonary hypertension and suggests that aerobic exercise may serve as a beneficial adjunctive therapy to modify vascular remodeling.
Pulmonary hypertension is a progressive disease of the pulmonary arteries that begins with increased pulmonary artery pressure, driven by progressive remodeling of the small pulmonary arteries, and ultimately leads to right heart failure and death. Vascular remodeling is the main pathological feature of pulmonary hypertension, but treatments for pulmonary hypertension are lacking. Determining the process of vascular proliferation and dysfunction may be a way to decipher the pathogenesis of pulmonary hypertension. In this review, we summarize the important pathways of pulmonary hypertension pathogenesis. We show how these processes are integrated and emphasize the benign role of aerobic exercise, which, as an adjunctive therapy, may be able to modify vascular remodeling in pulmonary hypertension.
Song et al. (Fri,) conducted a review in Pulmonary hypertension. Aerobic exercise was evaluated. Aerobic exercise serves as an effective adjunctive therapy for pulmonary hypertension by improving exercise capacity, reducing mean pulmonary arterial pressure, and modifying vascular remodeling.