Key result
Pine bark extract significantly protected against cisplatin-induced hepatotoxicity in rats, reducing serum AST levels from 174.7 IU/L to 132.0 IU/L at a dose of 20 mg/kg/day.
Why the study?
Does pine bark extract prevent cisplatin-induced hepatotoxicity and oxidative stress in rats?
Does pine bark extract prevent cisplatin-induced hepatotoxicity and oxidative stress in rats?
Pine bark extract protects against cisplatin-induced acute hepatotoxicity and oxidative stress in a rat model.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for pine bark extract in cisplatin hepatotoxicity; human trials needed before any clinical consideration.
We investigated the protective effects of pine bark extract (pycnogenol®, PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1) vehicle control, (2) cisplatin (7.5 mg/kg), (3) cisplatin & PYC 10 (10 mg/kg/day), and (4) cisplatin & PYC 20 (20 mg/kg/day). A single intraperitoneal injection of cisplatin induced hepatotoxicity, as evidenced by an increase in serum aminotransferase and histopathological alterations, including degeneration/necrosis of hepatocytes, vacuolation, and sinusoidal dilation. In addition, an increase in the malondialdehyde (MDA) concentration and a decrease in the reduced glutathione (GSH) content and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities were observed in the cisplatin-treated rat hepatic tissues. In contrast, PYC treatment effectively prevented cisplatin-induced hepatotoxicity, including the elevation of aminotransferase and histopathological lesions, in a dosedependent manner. Moreover, PYC treatment also induced antioxidant activity by decreasing MDA level and increasing GSH content and SOD and GST activities in liver tissues. These results indicate that PYC has a protective effect against acute hepatotoxicity induced by cisplatin in rats, and that the protective effects of PYC may be due to inhibiting lipid peroxidation and increasing antioxidant activity.
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Ko et al. (2014) studied Cisplatin-induced hepatotoxicity (n=24). Pine bark extract (pycnogenol) vs. Cisplatin alone (7.5 mg/kg) was evaluated on Serum aspartate aminotransferase (AST) level (IU/L) (p=<0.01). Pine bark extract significantly protected against cisplatin-induced hepatotoxicity in rats, reducing serum AST levels from 174.7 IU/L to 132.0 IU/L at a dose of 20 mg/kg/day.
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