A 12-month lifestyle and exercise intervention in patients with stage 3-4 CKD significantly improved peak Vo2 compared to standard care (2.8 vs -0.3 ml/kg per minute; P=0.004).
RCT (n=83)
Does a lifestyle intervention including exercise training improve cardiorespiratory fitness and cardiovascular function in patients with stage 3-4 CKD?
A 12-month lifestyle and exercise intervention in patients with stage 3-4 CKD significantly improves cardiorespiratory fitness, body composition, and diastolic function.
Absolute Event Rate: 2.8% vs -0.3%
p-value: p=0.004
BACKGROUND AND OBJECTIVES: CKD is associated with poor cardiorespiratory fitness (CRF). This predefined substudy determined the effect of exercise training and lifestyle intervention on CRF and explored the effect on cardiovascular risk factors and cardiac and vascular function. DESIGN, SETTING, PARTICIPANTS, P=0.004). There was small weight loss (-1.8±4.2 kg versus 0.7±3.7 kg; P=0.02) but no change in BP or lipids. Diastolic function improved (increased e' of 0.75±1.16 cm/s versus -0.47±1.0 cm/s; P=0.001) but systolic function was well preserved and did not change. The change in arterial elastance was attenuated (0.11±0.76 mmHg/ml versus 0.76±0.96 mmHg/ml; P=0.01). Δ peak Vo2 was associated with group allocation and improved body composition. CONCLUSIONS: Exercise training and lifestyle intervention in patients with CKD produces improvements in CRF, body composition, and diastolic function.
Howden et al. (Fri,) conducted a rct in Stage 3-4 CKD (n=83). Lifestyle intervention (multidisciplinary care, lifestyle program, and exercise training) vs. Standard care was evaluated on Cardiorespiratory fitness (change in peak Vo2) (p=0.004). A 12-month lifestyle and exercise intervention in patients with stage 3-4 CKD significantly improved peak Vo2 compared to standard care (2.8 vs -0.3 ml/kg per minute; P=0.004).