Key result
Chronic exercise training induces systemic endothelial adaptations that extend beyond active muscle beds to include vasculatures perfusing nonworking skeletal muscle, brain, viscera, and skin.
This review highlights that the vascular benefits of exercise extend beyond active muscle beds to include the endothelium of nonworking muscles, brain, viscera, and skin.
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Systemic endothelial benefits of exercise extend beyond active muscle; leaves open randomized trials for clinical outcome translation.
Endothelial adaptations to exercise training are not exclusively conferred within the active muscle beds. Herein, we summarize key studies that have evaluated the impact of chronic exercise on the endothelium of vasculatures perfusing nonworking skeletal muscle, brain, viscera, and skin, concluding with discussion of potential mechanisms driving these endothelial adaptations.
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Padilla et al. (2011) studied this question. Chronic exercise training induces systemic endothelial adaptations that extend beyond active muscle beds to include vasculatures perfusing nonworking skeletal muscle, brain, viscera, and skin.
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