Key result
Elevated waist-to-hip ratio linked to ~98% higher MI risk.
Why the study?
Clinical methods to predict the onset of myocardial infarction remain unsatisfactory, necessitating new predictive methods such as waist-to-hip ratio.
Does an elevated waist-to-hip ratio increase the risk of myocardial infarction in the general adult population?
Meta-Analysis (n=709,093)
Yes
Does an elevated waist-to-hip ratio increase the risk of myocardial infarction in the general adult population?
Effect estimate: OR 1.98 (95% CI 1.75-2.24)
An elevated waist-to-hip ratio is a significant predictor of myocardial infarction risk across multiple populations, with stronger associations seen in women and Asian cohorts.
WHR may aid MI risk stratification in adults; confirms association but leaves open incremental value and causality.
Background Myocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods. Objective To systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk. Methods Original literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale (NOS) and Revman5.3. Meta-analysis with Stata 16.0 calculated the combined Odd ratio (OR) for WHR and MI risk. Heterogeneity was assessed with the I 2 statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias. Results A total of 22 observational studies were included, involving 709,093 participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98 [95% Confidence interval (CI): 1.75–2.24] and high heterogeneity ( I 2 = 91.5%, P < 0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43–2.77) compared to men (OR: 1.74, 95% CI: 1.36–2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61–5.33), followed by American (OR: 1.73, 95% CI: 1.45–2.08) and European populations (OR: 2.19, 95% CI: 1.49–3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study. Conclusion In the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2024) conducted a meta-analysis in Myocardial infarction (n=709,093). Elevated waist-to-hip ratio was evaluated on Risk of myocardial infarction (OR 1.98, 95% CI 1.75-2.24). An elevated waist-to-hip ratio was significantly associated with an increased risk of myocardial infarction (OR 1.98; 95% CI 1.75-2.24).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: