Key result
Male sex linked to higher soft tissue and bone sarcoma incidence, particularly in childhood.
Why the study?
The biological mechanisms underlying sex differences in the incidence of soft tissue sarcomas remain largely unexplored.
This narrative review highlights the male sex predilection in soft tissue and bone sarcomas, particularly in childhood, and emphasizes the need to explore the underlying biological mechanisms to inform prevention and treatment.
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May warrant sex-specific risk awareness in pediatric sarcomas; leaves open biological mechanisms for future studies.
Cosci et al. (2023) conducted a review in Soft Tissue and Bone Sarcoma. Male sex is associated with a higher incidence of soft tissue and bone sarcomas, particularly in childhood, though the underlying biological mechanisms remain largely unexplored.
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