What does this research mean for the field?

The efficiency of E-selectin-mediated binding of colonic carcinoma cells to endothelial cells correlates with their metastatic potential, and this adhesion can be inhibited by soluble glycoproteins containing sialyl Le(x) termini. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Determine whether human colon carcinoma sublines with high versus low metastatic potentials differ in their adhesion efficiency to E-selectin-expressing cells.

January 1, 1994Journal of Biological ChemistryOpen Access

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.

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Authors

RSRitsuko SawadaJikei University School of Medicine STShigeru TsuboiKidney Research UK MFMichiko N. FukudaSouthern Illinois University Carbondale

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Implication

In vitro study reveals enhanced E-selectin adhesion in highly metastatic colon cancer cells, suggesting a targetable mechanism for metastatic spread.

Key Points

Determine whether human colon carcinoma sublines with high versus low metastatic potentials differ in their adhesion efficiency to E-selectin-expressing cells.
Assayed adhesion of high- and low-metastatic colon carcinoma sublines to activated human endothelial cells, Chinese hamster ovary cells stably expressing E-selectin, and interleukin-1 beta-activated mouse endothelioma cells.
Evaluated competitive inhibition of tumor cell adhesion using soluble lamp-1 and soluble leukosialin glycoproteins with or without sialyl Lewis(x) termini.
High metastatic colon carcinoma cells bound more efficiently than their low metastatic counterparts to activated human endothelial cells, E-selectin-expressing CHO cells, and activated mouse endothelioma cells.
Adhesion was selectively inhibited by soluble lamp-1 and soluble leukosialin possessing sialyl Lewis(x) termini, whereas glycoproteins lacking sialyl Lewis(x) structures failed to inhibit binding.

Cite This Study

Sawada et al. (1994) studied this question.

synapsesocial.com/papers/6a0c729f106bfae851886f07 https://doi.org/10.1016/s0021-9258(17)42275-7

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Implication

In vitro study reveals enhanced E-selectin adhesion in highly metastatic colon cancer cells, suggesting a targetable mechanism for metastatic spread.

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.

Discussion

Member takes

Implication

Key Points

Cite This Study

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.

Discussion

Member takes

Implication

Key Points

Cite This Study

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