Key result
Wide resection of extremity soft-tissue sarcoma yields ~65% long-term overall survival.
Why the study?
This study aimed to investigate the outcomes of wide resection of soft-tissue sarcoma of the extremities.
What are the outcomes of wide resection of soft-tissue sarcoma of the extremities?
Cohort (n=139)
No
What are the outcomes of wide resection of soft-tissue sarcoma of the extremities?
Wide resection of extremity soft-tissue sarcomas yields an overall survival of 64.7% and a recurrence rate of 10.1%, with surgical margins and tumor stage being critical factors.
Supports wide resection for extremity sarcomas in selected patients; leaves open optimal margins and adjuvant needs for prospective trials.
Background Soft-tissue sarcomas (STSs) are a rare heterogeneous group of tumors. Good functional results can be achieved with tumor excision in combination with suitable supplemental adjuvant therapies if needed. This study aimed to investigate the outcomes of wide resection of STS of the extremities. Methodology In this retrospective study, a total of 139 patients diagnosed with STS of the extremities by radiological and/or histopathological study/biopsy were included. All patients irrespective of metastasis were included. Results The mean age of the patients in our study was 43.5 ± 18.89 years. Overall, the mean tumor size was found to be 11.81 ± 6.218 cm. Malignant fibrous histiocytoma was the most common histology encountered (41%). Synovial sarcoma was the second most common histology encountered (14.38%). Recurrence was observed in 14 (10.1%) patients. The overall survival was 64.7% in our study. Conclusions The surgical margin achieved during the surgery is the most detrimental factor in local tumor control, and the overall survival of the patient after resection mainly depends on the stage of the tumor.
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Sheoran et al. (2022) conducted a cohort in Soft-tissue sarcoma of the extremity (n=139). Wide resection was evaluated on Overall survival. Wide resection of soft-tissue sarcoma of the extremities achieved an overall survival rate of 64.7% and a local recurrence rate of 10.1% over an 84-month follow-up.
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