Key result
Infiltrative growth linked to worse survival and local control in UPS and MFS patients.
Why the study?
Is infiltrative growth pattern associated with worse outcomes in patients with UPS and MFS?
Cohort (n=89)
No
Is infiltrative growth pattern associated with worse outcomes in patients with UPS and MFS?
Infiltrative growth on preoperative MRI is an adverse prognostic factor for survival and local control in patients with UPS and MFS, and postoperative radiotherapy does not salvage inadequately resected infiltrative tumors.
No takes yet. Share an insight, caveat, or question.
Infiltrative growth identifies higher-risk UPS/MFS patients on preoperative MRI; leaves open whether wider margins or intensified therapy improve outcomes.
Iwata et al. (2014) conducted a cohort in Undifferentiated pleomorphic sarcoma and myxofibrosarcoma (n=89). Infiltrative growth pattern vs. Non-infiltrative growth pattern was evaluated on Disease-specific and distant failure-free survival. Infiltrative growth, observed in 24% of patients with UPS and MFS, was an adverse prognostic factor for local control, disease-specific survival, and metastasis-free survival.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: