Why the study?
As a diagnosis of exclusion, undifferentiated pleomorphic sarcoma has unclear clinical characteristics, prompting investigation into which clinical and prognostic factors of primary lower-extremity disease determine failure.
What clinical and prognostic factors determine failure in patients with primary lower-extremity undifferentiated pleomorphic sarcoma?
What clinical and prognostic factors determine failure in patients with primary lower-extremity undifferentiated pleomorphic sarcoma?
Positive surgical margins and omission of radiation therapy are associated with worse outcomes in lower-extremity undifferentiated pleomorphic sarcoma.
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Positive margins associated with relapse and worse OS in lower-extremity UPS; supports margin-negative resection while leaving adjuvant selection open for prospective trials.
Kamat et al. (2018) studied this question.
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