Undifferentiated pleomorphic sarcoma of the extremity and trunk: a retrospective cohort study of 166 cases in a large institution

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  Figure 1. Macroscopic and HE staining pictures of tumor samples from UPS patients. (A) Isolated, leaf-like or fish-like masses, and the cut surface is mostly gray or white; (B,C) HE staining (10× and 40×), it appears as a mixed growth pattern of matted areas and polymorphic areas with a large number of polymorphic areas appearance. Multinucleated giant cells with chromatin and irregular nucle. HE, hematoxylin-eosin; UPS, undifferentiated pleomorphic sarcoma.

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  Figure 2. Kaplan-Meier curve for LRFS, DMFS and OS based on different prognostic variables. (A) Local recurrence-free survival rates, distant metastasis-free survival rates and overall survival rates at 3 and 5 years for 166 patients were 79.2% and 74.4%, 74.5% and 67.6% and 81.7% and 76.4%, respectively; (B-D) Kaplan-Meier curve for LRFS based on the gender, local recurrence at diagnosis and surgical margin. Patients with female, recurrence patients and R1/R2 have a worse LRFS than patients with male, no recurrence patience and R0 in all tumor groups; (E-H) Kaplan-Meier curve for DMFS based on the age, local recurrence at diagnosis, tumor location and surgical margin. Patients with age (>60 years), recurrence patients, trunk and R1/R2 have a worse DMFS than patients with age (≤60 years), no recurrence patients, extremity and R0 in all tumor groups; (I-L) Kaplan-Meier curve for OS based on the age, local recurrence at diagnosis, tumor size and surgical. Patients with age (>60 years), recurrence patients, tumor size (>5 cm) and R1/R2 after metastasis have a worse OS than patients with age (≤60 years), no recurrence patience, tumor size (≤5 cm) and R0 in all tumor groups. HR, hazard ratio;…