Key result
CACNA1C rs2239050 GG genotype linked to ~3x higher odds of BP control on amlodipine.
Why the study?
Response to antihypertensive medications varies among individuals, and understanding how genetic variations affect treatment outcomes is important for precision medicine.
Do single nucleotide polymorphisms in selected genes affect blood pressure response to amlodipine in patients with hypertension?
Case-Control (n=400)
Yes
Do single nucleotide polymorphisms in selected genes affect blood pressure response to amlodipine in patients with hypertension?
Specific genetic variants in CACNA1C, CACNA1D, and ACE genes significantly influence the blood pressure-lowering response to amlodipine in Pashtun patients with hypertension.
Answers are grounded in this paper and cite their sources.
Should not yet guide amlodipine selection by CACNA1C genotype; hypothesis-generating for pharmacogenomic personalization in hypertension.
Introduction: Despite the availability of various antihypertensive medications, the response to these medications varies among individuals. Understanding how individual genetic variations affect drugs treatment outcomes is a key area of focus in precision medicine. This study investigated the correlation between single nucleotide polymorphisms (SNPs) in selected genes (CACNA1C, CACNA1D, ABCB1, ACE, ADBR2, and NOS1AP) and the blood pressure (BP) control by amlodipine. Methods: Four hundred individuals of Pashtun ethnicity undergoing amlodipine treatment for hypertension were included in the present study and divided into the controlled (BP less than 140/90 mmHg) and uncontrolled (BP greater than 140/90 mmHg) hypertension groups. Blood samples (3 mL) were collected from each participant, and DNA was extracted using the Kit method. Ten SNPs in amlodipine pharmacogenes were selected and genotyped using real-time PCR with the TaqMan ® system. Logistic regression model was used to determine the association between SNPs and the amlodipine BP response. Results: Notable association were observed between SNP rs2239050/CACNA1C and amlodipine blood pressure response, with GG genotype carriers demonstrating a better response (P=0.004) than individuals carrying CC or CG genotypes. SNP rs312481/CACNA1D also exhibited a positive pharmacogenetic association, Individuals with the GG genotype showing a considerable reduction in BP (P=0.021) compared to participants with AA or GA genotypes. In case of SNP rs429/ACE individuals carrying TA genotype were less likely to achieve BP control (P=0.002) than AA genotype carriers. Conclusion: Our finding suggests that the SNPs rs2239050/CACNA1C, rs312481/CACNA1D and rs429/ACE influence amlodipine blood pressure response in patients with hypertension. It is recommended that prior knowledge of amlodipine associated pharmacogenetic variants is important that could improve its treatment outcomes in hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Jan et al. (2024) conducted a case-control in Hypertension (n=400). CACNA1C rs2239050 GG genotype (Amlodipine therapy) vs. CACNA1C rs2239050 CC or CG genotypes was evaluated on Controlled hypertension (<140/90 mmHg) (OR 3.05, 95% CI 2.76-20.08, p=0.006). The CACNA1C rs2239050 GG genotype was significantly associated with better blood pressure control in hypertensive patients treated with amlodipine compared to CC or CG genotypes (adjusted OR 3.05).
Synapse has enriched 10 related papers. Consider them for comparative context: