Key result
The presence of poorly differentiated areas in synovial sarcoma was strongly associated with local recurrence (HR 11.3; 95% CI 2.3-122.5; p=0.033), metastases, and tumor-related death.
Population
51 patients with synovial sarcoma in the Scottish Bone Tumor Registry from 1955 to 1999
Design
Cohort
Authors
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May warrant closer surveillance in synovial sarcoma with poor differentiation; leaves open histology-guided adjuvant decisions.
Cohort (n=51)
Effect estimate: HR 11.3 (95% CI 2.3-122.5)
p-value: p=0.033
Histologic features such as poorly differentiated areas, necrosis, and bone invasion are strong prognostic factors for adverse outcomes in synovial sarcoma and should inform adjuvant therapy decisions.
Silva et al. (2004) conducted a cohort in Synovial sarcoma (n=51). Poorly differentiated (PD) areas was evaluated on Local recurrence (HR 11.3, 95% CI 2.3-122.5, p=0.033). The presence of poorly differentiated areas in synovial sarcoma was strongly associated with local recurrence (HR 11.3; 95% CI 2.3-122.5; p=0.033), metastases, and tumor-related death.
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