What question did this study set out to answer?

Advocate for standardized grading criteria to assess pre-existing immunosuppression and stratify clinical risk in critically ill intensive care unit patients.

July 1, 2025EClinicalMedicineOpen Access

Advocating for the recognition of underlying immunosuppression in critical illness

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Advocate for standardized grading criteria to assess pre-existing immunosuppression and stratify clinical risk in critically ill intensive care unit patients.
Conducted a narrative review synthesizing current evidence on underlying diseases, immunosuppressive therapies, and variable infection risks in intensive care.
Formulated a preliminary three-tier risk stratification framework based on underlying disease states and treatment exposures.
Proposed a grading system categorizing immunosuppression into mild, moderate, and severe tiers to guide personalized clinical decision-making.
Identified that moderate immunosuppression warrants intensified infection surveillance, whereas severe immunosuppression indicates a potential need for early immune reconstitution therapies.
Emphasized the necessity of integrating clinical biomarkers and machine learning models in prospective studies to validate the grading system.

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Implication

Narrative review reveals the utility of tiered immunosuppression grading in critically ill patients, suggesting tailored infection surveillance and targeted immune reconstitution.

Cite This Study

Martín‐Loeches et al. (2025) studied this question.

synapsesocial.com/papers/6a0cabefc63d985fc0886063 https://doi.org/10.1016/j.eclinm.2025.103300

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Implication

Narrative review reveals the utility of tiered immunosuppression grading in critically ill patients, suggesting tailored infection surveillance and targeted immune reconstitution.

Advocating for the recognition of underlying immunosuppression in critical illness

Key Points

Discussion

Implication

Cite This Study

Advocating for the recognition of underlying immunosuppression in critical illness

Key Points

Discussion

Implication

Cite This Study

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