Comparative sequence analysis reveals limitations in detecting protein homology due to random chance and convergent evolution, highlighting challenges in reconstructing molecular evolutionary...
The systemic comparison of every newly determined amino acid sequence with all other known sequences may allow a complete reconstruction of the evolutionary events leading to contemporary proteins. But sometimes the surviving similarities are so vague that even computer-based sequence comparisons procedures are unable to validate relationships. In other cases similar sequences may appear in totally alien proteins as a result of mere chance or, occasionally, by the convergent evolution of sequences with special properties.
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Russell F. Doolittle (1981) studied this question.
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