What question did this study set out to answer?

Characterize the t(9;12)(p24;p13) chromosomal translocation identified in a pediatric acute lymphoblastic leukemia case and assess the functional effects of the resulting fusion protein.

November 14, 1997Science

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

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Authors

VPVirginie Penard‐LacroniqueInstitut Gustave Roussy ABAnthony BoureuxInserm VVVéronique Della ValleUniversité Paris-Sud

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Implication

Molecular study reveals constitutive kinase activation via TEL-JAK2 fusion in childhood leukemia, indicating a mechanism for cytokine-independent growth.

Key Points

Characterize the t(9;12)(p24;p13) chromosomal translocation identified in a pediatric acute lymphoblastic leukemia case and assess the functional effects of the resulting fusion protein.
Characterized the t(9;12)(p24;p13) chromosomal translocation in a pediatric patient with T-cell acute lymphoblastic leukemia to determine the joined gene partners.
Expressed the engineered TEL-JAK2 fusion transcript in interleukin-3-dependent Ba/F3 hematopoietic cells to evaluate kinase activation and cytokine dependence.
Identified that the translocation joins the 5' oligomerization domain of the TEL transcription factor to the 3' catalytic domain of the JAK2 tyrosine kinase.
Demonstrated that TEL-driven oligomerization causes constitutive tyrosine kinase activity, granting cytokine-independent growth to cytokine-dependent hematopoietic cells.

Cite This Study

Penard‐Lacronique et al. (1997) studied this question.

synapsesocial.com/papers/6a0cafa35ad8469bebe87c96 https://doi.org/10.1126/science.278.5341.1309

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Implication

Molecular study reveals constitutive kinase activation via TEL-JAK2 fusion in childhood leukemia, indicating a mechanism for cytokine-independent growth.

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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