What question did this study set out to answer?

To investigate how mechanical tension produced by growth cones influences their direction of advance and branching behavior.

Mechanical tension produced by nerve cells in tissue culture

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Randomized trial shows how mechanical tension affects neurite growth direction, indicating its role in cell behavior.

To investigate how mechanical tension produced by growth cones influences their direction of advance and branching behavior.
Cultured neurons were analyzed for mechanical tension during growth cone advancement, including vectorial analysis of isolated sensory neurons.
Experiments involved manipulating growth cones with microelectrodes to assess changes in direction due to applied tension.
Standard methods were used to calculate relative mechanical tension at branch points of neurite outgrowth.
Growth cones exert mechanical tension, affecting the direction of neurite advancement.
Directional changes occurred immediately when tension was altered using a microelectrode.
Increased probability of branching was observed following release of mechanical tension on the growth cone.

D. Bray (1979) studied this question.

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