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November 1, 1978Proceedings of the National Academy of SciencesOpen Access

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

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Authors

JNJack H. NunbergUniversity of MontanaRandal J. KaufmanRandal J. KaufmanDiscovery InstituteRSRobert SchimkeNational Institutes of Health

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Cite This Study

Nunberg et al. (1978) studied this question.

synapsesocial.com/papers/6a0cb1b4d48675e49423a67bhttps://doi.org/10.1073/pnas.75.11.5553
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Also Consider

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  1. 1CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM1965 · 842 citations
  2. 2Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.1976 · 170 citations
  3. 3Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells1978 · 93 citations
  4. 4TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA1977 · 482 citations