Key result
Infection with the OK10 virus complex in chickens was 100% lethal within 6-8 weeks, rapidly inducing tumors and demonstrating multiple oncogenic potential in vivo.
Population
2-4 day old Brown Leghorn chickens
Design
Preclinical
Follow-up
up to 1.5 years
Authors
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Establishes OK10 as highly oncogenic in chickens; leaves open relevance to mammalian or human disease.
The OK10 virus complex demonstrates rapid and multiple oncogenic potential in vivo in chickens.
L. Hortling (1978) studied OK10 virus infection and oncogenesis. OK10 virus complex was evaluated on Lethality and tumor formation. Infection with the OK10 virus complex in chickens was 100% lethal within 6-8 weeks, rapidly inducing tumors and demonstrating multiple oncogenic potential in vivo.
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