Having multiple cardiovascular risk factors (≥2) in hematopoietic cell transplantation survivors increased the 10-year incidence of cardiovascular disease compared to none (11.2% vs 4.7%, P<.01).
Cohort (n=1,885)
No
What is the incidence of cardiovascular risk factors and subsequent cardiovascular disease in hematopoietic cell transplantation survivors?
Hematopoietic cell transplantation survivors have a high prevalence of cardiovascular risk factors, which incrementally increase their risk of subsequent cardiovascular disease, particularly in those with prior anthracycline or chest radiation exposure.
Tasa de eventos absoluta: 11.2% vs 4.7%
valor p: p=<.01
Hematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors CVRFs); and these factors can potentially increase the risk of cardiovascular disease (CVD). We examined the incidence and predictors of CVRFs and subsequent CVD in 1885 consecutive 1+year survivors of HCT performed at City of Hope between 1995 and 2004. Ten-year cumulative incidence of hypertension, diabetes, dyslipidemia, and multiple (≥ 2) CVRFs was 37.7%, 18.1%, 46.7%, and 31.4%, respectively. The prevalence of CVRFs was significantly higher among HCT recipients compared with the general population; contributed to largely by allogeneic HCT recipients. Older age and obesity at HCT were associated with increased risk of CVRFs. History of grade II-IV acute graft versus host disease was associated with an increased risk for hypertension (relative risk RR = 9.1, P < .01), diabetes (RR = 5.8, P < .01), and dyslipidemia (RR = 3.2, P < .01); conditioning with total body irradiation was associated with an increased risk of diabetes (RR = 1.5, P = .01) and dyslipidemia (RR = 1.4, P < .01). There was an incremental increase in 10-year incidence of CVD by number of CVRFs (4.7% none, 7.0% 1 CVRF, 11.2% ≥ 2 CVRFs, P < .01); the risk was especially high (15.0%) in patients with multiple CVRFs and pre-HCT exposure to anthracyclines or chest radiation.
Armenian et al. (Fri,) conducted a cohort in Hematopoietic cell transplantation (HCT) survivors (n=1,885). Cardiovascular risk factors (CVRFs) vs. No CVRFs was evaluated on 10-year incidence of cardiovascular disease (CVD) (p=<.01). Having multiple cardiovascular risk factors (≥2) in hematopoietic cell transplantation survivors increased the 10-year incidence of cardiovascular disease compared to none (11.2% vs 4.7%, P<.01).