Key result
Food, particularly grapefruit juice, may affect the bioavailability of antihypertensive drugs, altering their therapeutic efficacy and causing potential toxic effects.
Why the study?
Does food, specifically grapefruit juice, interact with antihypertensive drugs to alter their efficacy or cause toxic effects?
Does food, specifically grapefruit juice, interact with antihypertensive drugs to alter their efficacy or cause toxic effects?
Food, especially grapefruit juice, can alter the bioavailability of antihypertensive drugs, highlighting the need for detailed dietary anamnesis and advising against grapefruit juice consumption during treatment.
Clinicians should screen for grapefruit juice use with antihypertensives; leaves open dedicated outcome trials for specific agents.
OBJECTIVE: A drug interaction is defined as any alteration, pharmacokinetics and/or pharmacodynamics, produced by different substances, other drug treatments, dietary factors and habits such as drinking and smoking. These interactions can affect the antihypertensive drugs, altering their therapeutic efficacy and causing toxic effects. The aim of this study was to conduct a review of available data about interactions between antihypertensive agents and food. METHODS: The purpose of this review was to report an update of main findings with respect to the interactions between food and antihypertensive drugs by way of a search conducted in PubMed, which yielded a total of 236 articles initially. RESULTS: After excluding different articles, which were not focusing on the specific objective, the main results refer to interactions between antihypertensive drugs and food (in general) as well as between antihypertensive agents and grapefruit juice. DISCUSSION: Food may affect the bioavailability of antihypertensive drugs and this should be carefully considered. Advising patients to remove the grapefruit juice from their diet when treatment with these drugs seems to be the best recommendation. Given these interactions and the associated potential adverse effects the anamnesis must include detailed information about the specific eating habits of the patients.
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Jáuregui et al. (2013) conducted a review in Hypertension. Antihypertensive drugs and food (grapefruit juice) was evaluated on Interactions between antihypertensive agents and food. Food, particularly grapefruit juice, may affect the bioavailability of antihypertensive drugs, altering their therapeutic efficacy and causing potential toxic effects.
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