Key result
Anastomotic leakage after curative resection for colorectal cancer was independently associated with worse overall survival (HR 1.6; 95% CI 1.2-2.0) and cancer-specific survival (HR 1.8).
Why the study?
Does anastomotic leakage reduce overall and cancer-specific survival in patients undergoing curative resection for colorectal cancer?
Population
1,722 consecutive patients undergoing potentially curative resection for colorectal cancer between 1971 and…
Comparison
Anastomotic leakage vs No anastomotic leakage
Design
Cohort
Follow-up
until death or to December 31, 2002
Authors
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Highlights need for leak prevention in colorectal resections; leaves open whether mitigation improves survival.
Cohort (n=1,722)
No
Does anastomotic leakage reduce overall and cancer-specific survival in patients undergoing curative resection for colorectal cancer?
Effect estimate: HR 1.6 (95% CI 1.2-2.0)
Absolute Event Rate: 44.3% vs 64%
Anastomotic leakage following curative resection for colorectal cancer is independently associated with diminished overall and cancer-specific survival.
Walker et al. (2004) conducted a cohort in Colorectal cancer (n=1,722). Anastomotic leakage vs. No anastomotic leakage was evaluated on Overall survival (HR 1.6, 95% CI 1.2-2.0). Anastomotic leakage after curative resection for colorectal cancer was independently associated with worse overall survival (HR 1.6; 95% CI 1.2-2.0) and cancer-specific survival (HR 1.8).
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