Why the study?
Does a history of both cancer and cardiovascular disease increase the risk of severe disease in patients with COVID-19?
Population
2,476 patients who tested positive for SARS-CoV-2 at 4 Massachusetts hospitals between March 11 and May 21…
Comparison
History of both cancer and cardiovascular disease vs History of cancer alone, cardiovascular disease…
Design
Cohort
Key result
Patients with both cancer and cardiovascular disease had a higher likelihood of COVID-19-associated severe disease compared with those with cancer alone (HR 1.86; 95% CI 1.11-3.10; P=0.02).
Authors
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Patients with cancer and CVD may warrant closer monitoring; extends observational comorbidity data but leaves open prospective validation.
Cohort (n=2,476)
Yes
Does a history of both cancer and cardiovascular disease increase the risk of severe disease in patients with COVID-19?
Effect estimate: HR 1.86 (95% CI 1.11-3.10)
p-value: p=0.02
Patients with COVID-19 and a history of both cancer and cardiovascular disease are at significantly higher risk for severe disease and death compared to those with either condition alone.
Ganatra et al. (2021) conducted a cohort in COVID-19 (n=2,476). History of both cancer and cardiovascular disease vs. History of either cancer or cardiovascular disease alone was evaluated on COVID-19-associated severe disease (composite of mechanical ventilation, shock, or death) (HR 1.86, 95% CI 1.11-3.10, p=0.02). Patients with both cancer and cardiovascular disease had a higher likelihood of COVID-19-associated severe disease compared with those with cancer alone (HR 1.86; 95% CI 1.11-3.10; P=0.02).