What question did this study set out to answer?

Review the cell biological and molecular mechanisms that Listeria monocytogenes uses to invade host cells, escape vacuolar degradation, and spread without damaging the host.

August 5, 2002The Journal of Cell BiologyOpen Access

The cell biology ofListeria monocytogenesinfection

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Authors

DPDaniel A. PortnoyLaguna Research VAVictoria AuerbuchUniversity of California, Santa Cruz IGIan J. GlomskiUniversity of Virginia

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Implication

Mechanistic review uncovers how Listeria monocytogenes exploits host cellular machinery to replicate and spread intercellularly, highlighting pathways critical for in vivo pathogenesis.

Key Points

Review the cell biological and molecular mechanisms that Listeria monocytogenes uses to invade host cells, escape vacuolar degradation, and spread without damaging the host.
Examined molecular interactions between bacterial virulence factors and host cytoplasmic machinery during intracellular infection.
Assessed the in vivo functional consequences of disrupting bacterial vacuolar escape and actin-based motility machinery.
The pore-forming toxin listeriolysin O mediates bacterial escape from host vacuoles through tightly regulated mechanisms that prevent premature host cell death.
The bacterial surface protein ActA recruits host Arp2/3 complexes and Ena/VASP family proteins to assemble actin tails that propel bacteria into adjacent cells.
Disruption of either vacuolar escape or actin-based intercellular motility substantially diminishes the capacity of L. monocytogenes to maintain productive in vivo infection.

Cite This Study

Portnoy et al. (2002) studied this question.

synapsesocial.com/papers/6a0cc2dd17d56fa39a4a458f https://doi.org/10.1083/jcb.200205009

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Implication

Mechanistic review uncovers how Listeria monocytogenes exploits host cellular machinery to replicate and spread intercellularly, highlighting pathways critical for in vivo pathogenesis.

The cell biology ofListeria monocytogenesinfection

Discussion

Member takes

Implication

Key Points

Cite This Study

The cell biology ofListeria monocytogenesinfection

Discussion

Member takes

Implication

Key Points

Cite This Study

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