What question did this study set out to answer?

Summarize the regulatory mechanisms through which gut microbiota, microbial species, and bacterial metabolites influence energy harvest, chronic inflammation, and adipose tissue biology in obesity.

April 4, 2025Journal of BacteriologyOpen Access

Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights

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Authors

MIM. IqbalCentral South University YQYu QianJiangnan University JTJingqun TangCentral South University

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Implication

Review reveals distinct microbial species and metabolites driving obesity in humans, highlighting the therapeutic potential of microbiota-targeted metabolic interventions.

Key Points

Summarize the regulatory mechanisms through which gut microbiota, microbial species, and bacterial metabolites influence energy harvest, chronic inflammation, and adipose tissue biology in obesity.
Narrative review synthesizing findings on specific obesogenic versus protective gut bacterial taxa and their molecular interactions.
Evaluation of metabolic pathways governed by bacterial metabolites, focusing on short-chain fatty acids, lipopolysaccharide translocation, and adipose tissue browning.
Species including Clostridium XIVb, Dorea spp., and Enterobacter cloacae promote obesity by elevating gut permeability, energy harvest, and lipopolysaccharide-mediated systemic inflammation.
Protective microbes such as Akkermansia muciniphila and Bifidobacterium spp. reinforce the gut epithelial barrier, modulate fasting-induced adipose factor, and stimulate beneficial metabolite synthesis.
Short-chain fatty acids activate G-protein coupled receptors to enhance white adipose tissue browning and thermogenesis, whereas systemic lipopolysaccharides drive insulin resistance and excess lipid storage.

Cite This Study

Iqbal et al. (2025) studied this question.

synapsesocial.com/papers/6a0cc2f517d56fa39a4a45ae https://doi.org/10.1128/jb.00479-24

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Implication

Review reveals distinct microbial species and metabolites driving obesity in humans, highlighting the therapeutic potential of microbiota-targeted metabolic interventions.

Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights

Discussion

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Implication

Key Points

Cite This Study

Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights

Discussion

Member takes

Implication

Key Points

Cite This Study

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