What question did this study set out to answer?

To evaluate the clinical utility of next-generation sequencing-based genomic profiling in directing diagnosis and therapy for patients with advanced sarcomas.

October 19, 2018JCO Precision OncologyOpen Access

Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience

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Authors

SBSpandana BodduMaine Farmland Trust CWChristine M. WalkoMoffitt Cancer Center SBStephanie BienaszMaine Farmland Trust

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Implication

Retrospective study demonstrates actionable genomic alterations in nearly half of advanced sarcoma cases, suggesting potential utility for refining diagnosis and guiding targeted therapy.

Key Points

To evaluate the clinical utility of next-generation sequencing-based genomic profiling in directing diagnosis and therapy for patients with advanced sarcomas.
Retrospective chart review of next-generation sequencing results performed on tumor samples from N=114 patients diagnosed with non-gastrointestinal stromal tumor sarcomas at a single institution.
Clinical impact was assessed by reviewing molecular tumor board determinations of actionable findings, diagnostic changes, and treatment response.
Potentially oncogenic alterations were identified in 96.7% of tumors (median 3 alterations per tumor, range 0 to 19), with actionable findings identified in 49.1% (56/114) of patients.
Sequencing results altered the diagnosis in 4.4% (5/114) of patients and guided systemic therapy selection in 13.2% (15/114).
Clinical benefit occurred in 26.7% (4/15) of patients who received genomic profiling-influenced systemic therapies.

Cite This Study

Boddu et al. (2018) studied this question.

synapsesocial.com/papers/6a0cc3d417d56fa39a4a4672 https://doi.org/10.1200/po.18.00096

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Implication

Retrospective study demonstrates actionable genomic alterations in nearly half of advanced sarcoma cases, suggesting potential utility for refining diagnosis and guiding targeted therapy.

Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience

Discussion

Member takes

Implication

Key Points

Cite This Study

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