Key result
CRP1 directly interacts with the 27-kD actin-binding domain of alpha-actinin with a Kd of 1.8 +/- 0.3 microM, which is sufficient to localize CRP1 to the actin cytoskeleton.
Population
Avian smooth muscle extract, chick embryo fibroblasts (CEF), and smooth muscle cells
Design
Preclinical
Authors
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May guide myogenesis research; leaves open CRP1's essential role in vivo.
Effect estimate: Kd 1.8 +/- 0.3 microM
CRP1 directly interacts with alpha-actinin via its NH2-terminal domain, which is sufficient to localize CRP1 to the actin cytoskeleton and may be critical for muscle differentiation.
Pomiès et al. (1997) studied Muscle differentiation. CRP1 directly interacts with the 27-kD actin-binding domain of alpha-actinin with a Kd of 1.8 +/- 0.3 microM, which is sufficient to localize CRP1 to the actin cytoskeleton.
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