What question did this study set out to answer?

To review the mechanisms through which the human gut microbiota facilitates antimicrobial resistance and evaluate strategies to mitigate multidrug-resistant colonization.

May 20, 2025Frontiers in MicrobiologyOpen Access

The gut microbiome: an emerging epicenter of antimicrobial resistance?

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Authors

SDSushil V. Deshpande SSSwathi SujithSASTRA University RJRenitta JobbyCzech Academy of Sciences, Institute of Biotechnology

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Implication

Review highlights antimicrobial resistance gene acquisition in the human gut, indicating an urgent need for targeted colonization prevention strategies.

Key Points

To review the mechanisms through which the human gut microbiota facilitates antimicrobial resistance and evaluate strategies to mitigate multidrug-resistant colonization.
Narrative synthesis of literature regarding microbial density, gene transfer pathways, and pathogen colonization dynamics in the gut.
Assessment of clinical burdens related to multidrug-resistant infections and appraisal of current infection control protocols.
The densely populated human gut environment actively accelerates the horizontal transfer and accumulation of antimicrobial resistance genes among commensal and pathogenic bacteria.
Multidrug-resistant infections originating in or colonizing the gut increase hospital stay duration, relapse rates, and overall healthcare costs, demonstrating the limitations of relying solely on existing nosocomial control protocols.

Cite This Study

Deshpande et al. (2025) studied this question.

synapsesocial.com/papers/6a0cc641c031bbff4134c326 https://doi.org/10.3389/fmicb.2025.1593065

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Implication

Review highlights antimicrobial resistance gene acquisition in the human gut, indicating an urgent need for targeted colonization prevention strategies.

The gut microbiome: an emerging epicenter of antimicrobial resistance?

Discussion

Member takes

Implication

Key Points

Cite This Study

The gut microbiome: an emerging epicenter of antimicrobial resistance?

Discussion

Member takes

Implication

Key Points

Cite This Study

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