Key result
Combined r-tPA and EVT improves expected QALYs vs r-tPA alone if reperfusion takes under 347 minutes.
Why the study?
Does combined intravenous r-tPA and endovascular therapy improve quality-adjusted life years compared to intravenous r-tPA alone in patients with acute ischemic stroke and large vessel occlusion?
Does combined intravenous r-tPA and endovascular therapy improve quality-adjusted life years compared to intravenous r-tPA alone in patients with acute ischemic stroke and large vessel occlusion?
Absolute Event Rate: 6.38% vs 5.42%
Endovascular therapy combined with intravenous r-tPA is the preferred treatment strategy over intravenous r-tPA alone for acute ischemic stroke with large vessel occlusion, provided time to reperfusion does not exceed 347 minutes.
No takes yet. Share an insight, caveat, or question.
May support combined r-tPA and endovascular therapy in eligible large vessel occlusion; leaves open prospective randomized validation.
Vagal et al. (2014) studied Acute Ischemic Stroke with large vessel occlusion. Combined intravenous r-tPA and endovascular therapy vs. Intravenous r-tPA alone was evaluated on Expected utility (quality-adjusted life years). Combined intravenous r-tPA and endovascular therapy yielded a higher expected utility (6.38 vs 5.42 QALYs) than intravenous r-tPA alone, provided time to reperfusion did not exceed 347 minutes.
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