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May 3, 2016ecancermedicalscienceOpen Access

Ovarian cancer in BRCA1 and BRCA2 gene mutation carriers: analysis of prognostic factors and survival

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Authors

NBNicoletta BigliaPSPaola SgandurraVBValentina Elisabetta Bounous

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Overview

Randomized trial compares outcomes of ovarian cancer in BRCA mutation carriers and non-carriers, indicating better prognosis for BRCA+ patients.

Key Points

  • To analyze and compare clinical-pathological characteristics and outcomes in BRCA mutation carriers versus sporadic ovarian cancer patients.
  • Enrolled 24 BRCA1/2 positive patients and 64 age-matched controls without family history of breast/ovarian cancer.
  • Compared clinical-pathological characteristics, surgical outcomes, overall survival (OS), and progression-free survival (PFS) between groups.
  • Performed statistical analysis on differences in histotype, stage at diagnosis, and survival outcomes.
  • BRCA+ patients had a higher rate of high-grade serous histotype (70.8% vs 53.1%, p > 0.05).
  • 20.83% of BRCA+ patients were diagnosed at stage II compared to 4.69% in controls (p = 0.024).
  • PFS for BRCA+ patients was significantly longer (60 months) compared to controls (22 months, p = 0.039).

Cite This Study

Biglia et al. (2016) studied this question.

synapsesocial.com/papers/6a0cc8a259b087b0dc62578fhttps://doi.org/10.3332/ecancer.2016.639
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of BRCA Mutation Status with Clinical Outcomes in High-Grade Serous Ovarian Cancer2026
  2. 2Does BRCA Mutation Status Influence Ovarian Cancer Onset Timing and Patients’ Treatment Outcomes?2025
  3. 3Comparison of Overall Survival, Progression Free Survival (PFS), Treatment Free Interval (TFI) between BRCA1 and BRCA2 Associated Epithelial Ovarian Cancer2024
  4. 4Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden.1998 · 256 citations
  5. 5Genetic and Clinical Implications of BRCA Mutations in Hereditary Breast and Ovarian Cancer Syndrome (HBOC): A Review2024