Many studies have shown that clindamycin may cause pseudomembranous colitis, a potentially fatal complication. At present, prevention of this complication depends on (1) prescription of the drug only for specific severe infections, (2) early investigation and discontinuation of clindamycin if diarrhea ensues, and (3) vigorous supportive therapy.
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Francis J. Tedesco (1977) studied this question.
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